Communication with the Chandrayaan 2 lander was lost a few seconds before it was supposed to touch down on the moon's surface, chief of Indian Space Research Organisation (ISRO) said.
India hoped to create history by becoming the first nation to reach closest to the Moon's south pole but as 1:55 am (Indian time) came and went there were no signs that the mission had succeeded.
Indian Prime Minister Narendra Modi who was watching the landing from the mission control room was briefed by the ISRO scientists and was seen leaving, the NDTV reports.
Vikram, the lander of Chandrayaan 2, was scheduled to touch down between 1:30-2:30 am today. It used rocket thrusters to slow itself down to attempt the extremely tricky operation that ISRO called "15 minutes of terror".
It was at this point, about 2.1 km from the surface, that contact was lost.
"There are ups and downs in life. This is not a small achievement. The nation is proud of you. Wish you the very best. I congratulate you. You all have done a big service to the nation, science, and mankind. I am with you all the way, move forward bravely," PM Modi told the scientists.
"Vikram lander's descent was as planned and normal performance was observed up to an altitude of 2.1 km. Subsequently, communication from the lander to the ground was lost. The data is being analyzed," ISRO chief K Sivan told the Indian online news Portal. Dr Sivan had called Chandrayaan 2 the "most complex mission ever undertaken by ISRO".